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The structure reveals details of TLR3 that have never been seen before, an essential step toward fully understanding the critical role this protein—and other TLRs—play in the human innate immune system to rapidly detect invading pathogens
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“What we found was an unusual configuration of the antibody in which its two Fab domains—the antigen recognition units—are ‘interdigitating’ with each other,” says TSRI Professor Ian Wilson, one of two TSRI professors who led the research. “Nothing like this has ever been seen before.”
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