Wilson Laboratory

Our major goals are to understand the interaction and neutralization of foreign antigens by the immune system through structural studies
Broadly neutralizing antibodies targeting hemagglutinin stem revitalized hopes of a universal flu vaccine.
The first atomic-level structure of the HIV envelope trimer — long considered one of the most difficult targets in structural biology.
Crystal structure of an antigenically near-native, cleaved, stabilized, soluble HIV-1 Env trimer
VH1-69 antibodies that broadly neutralize almost all influenza A group 1 viruses constituted a breakthrough in the influenza field
The x-ray and electron microscopy structures differ markedly from predictions and provide valuable information for HCV drug and vaccine design
The Ultimate Decoy: Scientist Find Unique Protein That Misdirects Immune System
Integrative approaches using data from a wide variety of methods are yielding model structures of complex biological assemblies.

X-ray Crystallography

Characterization of Foreign Antigens Recognition by the Immune System.

Facilities & Resources

Hight Throughput / Integrative Structural Biology and Biophysical Facilities & Resources

News & Highlights

Progress Towards the Neutralization of Viral Pathogens such as FLU and HIV-1

Gravityscan Badge