Scripps Research and Rockefeller Scientists Work on Obesity Therapy as Proof-of-Principle.

Cocaine-binding antibodies have shown some promise in their ability to neutralize cocaine toxicity, but their binding ability is severely impaired by high concentrations of the drug.

The JCSG investigators have incorporated new methods and technologies into an effective robotic pipeline for producing proteins and determining structures. Their efforts will advance the goals of the Protein Structure Initiative and lead to many benefits for the scientific community,” said John Norvell, director of the Protein Structure Initiative.

The first such structure of a CD1 molecule with a microbial antigen bound. It is also the first time the structure of a lipopeptide that is presented to the immune system has been solved

“This antibody is very broadly active,” says Scripps Research Professor Dennis Burton, who led the research with Scripps Research Professor Ian Wilson. “It neutralized nearly 100 different viral strains of HIV from all over the world. [During tests in the laboratory], every one of them was neutralized.”

“This opens the door to the possibility of using the glycan array as a surveillance tool for monitoring individual strains of influenza in birds and humans,” says Paulson, who is the director of the Consortium for Functional Glycomics at The Scripps Research Institute.

“This represents the first structure to be determined of an antibody from a non-mammalian species in complex with its antigen,” says Professor Ian Wilson, who is an investigator in the Skaggs Institute for Chemical Biology at Scripps Research.